AIOOIA NMN LONGEVITY TRILLIUM 60CAPS

What are the most compelling health benefits of NMN supplements?

The most compelling health benefits of NMN (Nicotinamide Mononucleotide) supplements, as supported by current research, include:

1. Boosts Brain Function: NMN supplementation improves brain function by increasing blood flow and oxygen supply to the brain, which may enhance cognitive abilities and protect against neurodegenerative diseases (9) (11)(12). *

2. Enhances Muscle Function: NMN helps improve muscle strength and endurance, potentially reversing age-related muscle decline and promoting better physical performance (9) (11). *

3.Promotes Heart Health: NMN has been shown to protect against heart failure by reducing cardiac scarring and improving overall cardiovascular function (12)(18).

4.Supports Insulin Sensitivity: NMN supplementation may improve insulin sensitivity, which is beneficial for metabolic health and can help prevent conditions like type 2 diabetes (12)(18). *

5.Increases Energy Levels: By boosting NAD+ levels, NMN enhances cellular energy production, which can reduce fatigue and improve overall vitality  (9) (11)(12). *

6.Anti-Aging Benefits: NMN is involved in NAD+ biosynthesis, which plays a crucial role in DNA repair and cellular maintenance, potentially slowing down the aging process and extending lifespan(9) (11)(12). *

7.Protects Against Obesity and Diabetes: NMN helps in maintaining a healthy metabolism and can protect against obesity and related metabolic disorders  (9) (11).*

These benefits highlight NMN's potential as a powerful supplement for promoting overall health and longevity, although more human studies are needed to fully understand its effects. *

Research:

Several studies have investigated the long-term effects of NMN (Nicotinamide Mononucleotide) supplementation, providing insights into its potential benefits and safety:

1. Lifespan and Health span in Mice:

A study demonstrated that chronic NMN treatment increased lifespan and healthspan in a sex-dependent manner in mice. Both male and female mice showed delayed frailty, with female mice experiencing increased lifespan and male mice showing improvements in metabolic health and physical activity. The treatment also led to a significant increase in a beneficial gut bacterium, Anaerotruncus colihominis, which is associated with reduced inflammation(1), (2).

2.Metabolic Health and Frailty:

Another study highlighted that long-term NMN supplementation delayed the onset of frailty in both male and female mice and improved metabolic health in male mice. The study also observed sex-specific effects on NAD+ metabolism, which may explain the differences in lifespan and health benefits between sexes (2).

3.Human Studies:

Research in humans has shown that NMN supplementation is safe and well-tolerated, even at higher doses (up to 1,200 mg per day). Studies have reported improvements in muscle insulin sensitivity, insulin signaling, and muscle performance, particularly in older adults (5). Additionally, NMN supplementation has been associated with increased NAD+ levels in blood and potential improvements in physical performance and endurance (3) .

These studies provide compelling evidence that NMN supplementation can offer significant health benefits, particularly in terms of delaying frailty, improving metabolic health, and potentially extending lifespan. However, more research, especially long-term human studies, is needed to fully understand the extent of these benefits and their applicability to humans.

There are several ongoing clinical trials investigating the long-term effects of NMN (Nicotinamide Mononucleotide) supplementation. Here are some key points about current research:

1. Increasing Number of Trials: As of March 2024, there were at least 21 registered clinical trials for NMN on clinicaltrials.gov (1). This indicates growing interest in studying the long-term effects of NMN supplementation in humans.

2.Safety and Tolerability: Studies have shown that NMN supplementation is safe and well-tolerated, even at higher doses up to 1,200 mg per day (2). This provides a foundation for longer-term studies.

3.Metabolic Health: A 10-week randomized; placebo-controlled, double-blind trial evaluated the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes. The study found that NMN improved muscle insulin sensitivity and insulin signaling (2).

4.Physical Performance: Research has shown that NMN supplementation can improve physical performance, particularly in older adults. A study on healthy men aged 65 or older demonstrated that 250 mg/day of NMN for 12 weeks was safe and partly improved muscle performance (2).

5.Ongoing Research: While many studies have been relatively short-term (6-12 weeks), there are ongoing efforts to investigate the long-term effects of NMN supplementation. These studies aim to provide more comprehensive data on the supplement's impact on aging-related disorders and overall health (2).

6.Personalized Approaches: Recent research is exploring personalized NMN supplementation. A double-blinded, randomized clinical trial found that NMN supplementation increased blood NAD concentrations, which could lead to better functional outcomes and quality of life among middle-aged and older adults (6).

7.Dose-Dependent Effects: Studies are investigating various dosages, with some experts recommending daily intakes of 900-1000mg for optimal benefits. However, more research is needed to establish definitive long-term dosage guidelines.

While these studies provide promising insights, it's important to note that more extensive, long-term human trials are still needed to fully understand the effects of NMN supplementation over extended periods.